RESERPINE AND VASCULAR TONE *

Taurine and vascular tone modulation

Taurine, an ubiquitary amino acid in the organism, has important physiological functions like bile salt formation, neuronal excitability regulation, immunomodulation, electrolytes homeostasis preservation, osmoregulation, membrane stabilisation, apoptosis inhibition and cell protection. This review article is focusing on the complex vasoactive influence of the sulphur-amino acid and on the poss...

Ion channels and vascular tone.

Ion channels in the plasma membrane of vascular muscle cells that form the walls of resistance arteries and arterioles play a central role in the regulation of vascular tone. Current evidence indicates that vascular smooth muscle cells express at least 4 different types of K(+) channels, 1 to 2 types of voltage-gated Ca(2+) channels, >/=2 types of Cl(-) channels, store-operated Ca(+) (SOC) chan...

Agonist-induced vascular tone.

The cellular mechanisms underlying the agonist-induced sustained contraction of the vascular smooth muscle are reviewed in the light of the use of Ca2+ and the change of Ca2+ sensitivity of the contractile apparatus. It is generally accepted that the main trigger for contraction of vascular smooth muscle is the elevation of intracellular Ca2+ concentration. However, the measurement of intracell...

Endothelial regulation of vascular tone.

Effects of Small Oral Doses of Reserpine on Vascular

IN ANIMALS, reserpine depletes tissues of catecholamines, -3 reduces the response of smooth muscle to tyramine,4' 5 and potentiates the action of norepinephrine.4 6, The decreased response to tyramine probably results from depletion, since the action of this sympathomimetic amine appears to be mediated through the release of norepinephrine.4-6 The cause of hypersensitivity to exogenous norepine...